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What is the opposite of without pain?

Need antonyms for without pain? Here's a list of opposite words from our thesaurus that you can use instead.

Affected with, or causing, physical discomfort or pain
“Mr. Miyagi would rub his hands together before applying them to the painful area of Daniel San's shoulder.”
(of a disease or symptom) Very bad or severe
“If you have a particularly strong flu, your doctor may check for pneumonia.”
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