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What is the opposite of insignificantly?

Need antonyms for insignificantly? Here's a list of opposite words from our thesaurus that you can use instead.

Opposite of so small or slight that it may be ignored
(a little) Opposite of only slightly
“You'll need to move substantially to the right so that we can get the perfect natural lighting for the photo.”
Opposite of to a negligible degree
“As soon as he left the unremunerative world of crime for a steady job with the forces of order, he became significantly more intelligent.”
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