| He apparently had two sons, Alexander IV of Macedon by Roxana and, possibly, Heracles of Macedon from his mistress Barsine. |
| From about 200 BC the Roman Republic became increasingly involved in Greek affairs and engaged in a series of wars with Macedon. |
| His father Nicomachus was the personal physician to King Amyntas of Macedon. |
| There was another son of Antipater, however, named Nicanor, who was then in Macedon. |
| Hellenic infighting left Greek city states vulnerable, and Philip II of Macedon united the Greek city states under his control. |
| News of Philip's death roused many states into revolt, including Thebes, Athens, Thessaly, and the Thracian tribes north of Macedon. |
