What is another word for serious complication?

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Noun An issue or problem that is severe in nature big problem dilemma predicament difficulty fix problem crisis mess pickle quandary conundrum jam perplexity muddle trouble bind corner huge problem double bind serious problem catch-22 difficult situation large problem major obstacle serious dilemma sticky situation tight corner tight spot tricky situation no-win situation serious predicament large difficulty spot of bother impasse quagmire scrape awkward situation rabbit hole embarrassment vicious circle strait confusion plight hole puzzle mire catch spot indecision uncertainty poser bother sticky wicket swamp difficult choice rattrap facer conflict box bad news sorry condition hell crash mishap extremity setback upheaval trauma adversity chaos issue pass entanglement shock misfortune imbroglio monstrosity critical situation distress debacle tinderbox meltdown hardship train wreck hassle problematic situation cataclysm shambles affliction situation big trouble stress fiasco horror desolation tribulation reverse dire straits hell on earth disorder reversal tragedy scourge holocaust deep water apocalypse unfortunate situation emergency bomb woe trial shipwreck misadventure hot potato blow hot water ruin hang-up worst-case scenario turmoil reversal of fortune disarray blight pressure failure exigency disorderliness complication car crash tight situation disaster devastation drama calamity urgency catastrophe havoc double trouble messiness heavy blow bust whammy pinch sad state stroke of ill luck stew hard times depression collapse “The risk of serious complication was lower in those who had treatment for diabetes.” Find more words! 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